After decades of work, why don’t we have an HIV vaccine?

All these tiny breaks in the case could add up over time. “I wouldn’t be surprised if in a decade we have a vaccine with 50 percent protection,” Pulendran says. (That’s on par with the flu shot.) Paired with existing stopgaps, that could be what it takes to outmaneuver the powerful germ—no sci-fi cure-alls required.

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