Moderna’s COVID-19 vaccine rarely causes severe allergic reactions, according to new data released by the Centers for Disease Control and Prevention (CDC).
Between Dec. 21 and Jan. 10, more than 4.04 million people were given Moderna’s COVID-19 vaccine, but only 10 developed a serious, potentially life-threatening allergic reaction called anaphylaxis. That works out to be around 2.5 cases of anaphylaxis per 1 million people vaccinated, according to the CDC’s Morbidity and Mortality Weekly Report.
It’s not yet clear what’s causing the severe allergies, but nine out of 10 of these cases occurred among patients with previously known allergies (five previously had anaphylaxis). Most had
allergies to various medicines such as penicillin, but one had environmental and food allergies and another didn’t have any prior known allergies, according to the report.
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Nine out of 10 of the patients developed symptoms — such as vomiting, nausea, wheezing, tongue swelling and rash — within 13 minutes of getting the vaccine and one developed symptoms within 45 minutes.
All 10 patients were treated with epinephrine — a hormone also known as adrenaline that is the key ingredient in EpiPens and similar autoinjectors; four were treated in an emergency department and six were hospitalized, with four requiring intubation. But all 10 patients recovered, according to the report.
“Based on this early monitoring, anaphylaxis after receipt of Moderna COVID-19 vaccine appears to be a rare event,” the authors wrote in the report. But because there’s not yet widespread data on COVID-19 vaccines, it’s difficult to compare the risk of anaphylaxis with non-COVID-19 vaccines, they wrote. In a previous Morbidity and Mortality Weekly Report, published on Jan. 15, researchers estimated that the Pfizer-BioNTech vaccine causes anaphylaxis in about 11.1 cases per million doses (0.001% chance); that estimate was based on early data.
Still, both the anaphylaxis associated with both Pfizer’s and Moderna’s COVID-19 vaccines seems to be above the average number of anaphylaxis cases found for previous vaccines. In 2015, researchers calculated that the chance of developing a severe allergic reaction to a vaccine is about 1.31 in 1 million, according to a 2015 study published in the Journal of Allergy Clinical Immunology. “True allergic reactions to vaccines are very rare,” Dr. Purvi Parikh, allergist and immunologist at NYU Langone Health, previously told Live Science. “Statistically, you’re more likely to be hit by lightning than have a true anaphylactic reaction to a vaccine.” Though the cases are extremely rare — and should not dissuade people from getting the vaccine — experts are working on identifying what could be causing the allergies.
People who have had an allergic reaction to the first dose of the vaccine should not receive the second dose, the authors wrote. Vaccine centers should have all the necessary supplies and trained staff to treat anaphylaxis, they wrote. The CDC also recommends that people who receive COVID-19 vaccines should also be monitored for about 15 minutes, or 30 minutes if they have a history of allergies or anaphylaxis.
Originally published on Live Science.
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