The evolution of single amyloid fibrils into microcrystals

Nanomechanical properties of ILQINS fibrils. a) AFM height, b) 3D AFM height, c) AFM amplitude, and d) AFM DMT modulus of ILQINS fibrils. e) DMT modulus of ILQINS fibrils from part (d). f) The histogram of DMT moduli of ILQINS fibrils. Credit: Advanced Science, doi:10.1002/advs.202002182 Amyloids refer to abnormal fibrous extracellular and proteinaceous deposits found […]

Diabetes increases neuritic damage around amyloid plaques in Alzheimer’s disease

New research from the University of Eastern Finland explores the role of diabetes in the cellular and molecular changes underlying Alzheimer’s disease (AD). In an AD mouse model, diabetes induced through a diet rich in fats and sugars weakened the accumulation of microglial cells around amyloid plaques and increased the formation of neuritic plaques with […]