Scientists reveal mechanism that causes irritable bowel syndrome — ScienceDaily

KU Leuven researchers have identified the biological mechanism that explains why some people experience abdominal pain when they eat certain foods. The finding paves the way for more efficient treatment of irritable bowel syndrome and other food intolerances. The study, carried out in mice and humans, was published in Nature. Up to 20% of the […]

Multi-population risk scores could improve risk prediction for inflammatory bowel diseases, study finds

Using genetic data from nearly 30,000 people, Mount Sinai researchers have built risk scores from a combination of datasets representing distinct ancestral populations that improve prediction of risk for inflammatory bowel diseases (IBD) including Crohn’s disease and ulcerative colitis. The study was published in Gastroenterology on December 24. The researchers found that polygenic risk scores, […]

Specific bacterium in the gut linked to irritable bowel syndrome (IBS) — ScienceDaily

Researchers at the University of Gothenburg have detected a connection between Brachyspira, a genus of bacteria in the intestines, and IBS — especially the form that causes diarrhea. Although the discovery needs confirmation in larger studies, there is hope that it might lead to new remedies for many people with irritable bowel syndrome. The pathogenic […]

People with inflammatory bowel disease still die earlier despite increase in life

A study comparing life expectancy of people with inflammatory bowel disease (IBD) and without found that, while life expectancy increased for both groups, people with IBD generally died sooner. The study is published in CMAJ (Canadian Medical Association Journal). “The good news is life expectancy has increased in people with IBD, but there is still […]

Inhibitor of KRAS gene mutation shows promise in lung, bowel and other solid tumors

IMAGE: Patient CT scans before and after treatment with adagrasib. Yellow arrow marks location of main tumor. view more  Credit: Pasi A. Jänne New results from early clinical trials of a drug that targets a cancer-causing mutation in the KRAS gene have shown that it can shrink tumours and is well-tolerated by patients. In two presentations […]

Targeted inhibitor of mutated KRAS gene shows promise in lung, bowel, & other solid tumors

IMAGE: Pasi A. Jänne, MD, PhD view more  Credit: Dana-Farber Cancer Institute A novel agent that targets a mutated form of the KRAS gene – the most commonly altered oncogene in human cancers and one long considered “undruggable” – shrank tumors in most patients in a clinical trial with manageable side effects, researchers reported today at […]