Creating a safe CAR T-Cell therapy to fight solid tumors in children — ScienceDaily

Chimeric Antigen Receptor T-cell therapy — CAR T — has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumors including childhood cancers such as neuroblastoma. Preclinical studies using certain CAR T against neuroblastoma revealed toxic effects. Now, a group of scientists at Children’s Hospital Los Angeles have developed a modified […]

The coolest car screens and displays from CES

The head-up display shows information like speed in the near view, and augmented-reality data superimposed over real-world features in the far view. (Panasonic /) Glancing down at an analog gauge in your vehicle to see if you’re pushing the speed limit, or need to find a gas station, is a reliable method for finding the […]

Gifts that every car owner should have

These items can make your ride feel complete. (tytbil88 / Deposit Photos/) A new set of wheels perfectly captures the American ideals of freedom, independence, and capitalism. Less sexy and thrilling—though still important—are the little gadgets that can make the vehicle even more practical. If you know someone who bought a car during the pandemic, […]

CRISPR-edited CAR T cells enhance fight against blood cancers — ScienceDaily

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells’ ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn’s Abramson Cancer Center. The findings will be […]

Scientists solve mystery of mass coho salmon deaths. The killer? A chemical from car tires

Coho salmon, Tillamook State Forest, Oregon. Credit: Oregon Department of Forestry When officials in Seattle spent millions of dollars restoring the creeks along Puget Sound—tending to the vegetation, making the stream beds less muddy, building better homes for fish—they were thrilled to see coho salmon reappear. But when it rained, more than half, sometimes all, […]

CRISPR-edited CAR T cells enhance fight against blood cancers

PHILADELPHIA– Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells’ ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn’s Abramson Cancer Center. The findings will […]

Research reveals how airflow inside a car may affect COVID-19 transmission risk

IMAGE: A new study looks at how airflow patterns inside the passenger cabin of a car might affect the transmission of SARS-CoV-2 and other airborne pathogens. Using computer simulations, the study… view more  Credit: Breuer lab / Brown University PROVIDENCE, R.I. [Brown University] — A new study of airflow patterns inside a car’s passenger […]

Salmon are dying off and your car tires might be to blame

Scientists found that a number of coho salmon died while swimming through urban waterways in the Pacific Northwest. (CREDIT: John R. McMillan, NOAA Fisheries/NWFSC/) Every fall, coho salmon undertake an epic journey from the ocean back to the freshwater streams and creeks where they were born so they can reproduce and then die shortly after. […]

CAR T-cell therapy found highly effective in patients with high-risk non-Hodgkin lymphoma

A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial, Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting. While NHL tends to be a slow-growing disease, […]