Botulism breakthrough? Taming botulinum toxin to deliver therapeutics

IMAGE: The toxin-based delivery platform consists of the modified botulinum toxin at upper left (protease domain in gold, translocation domain in blue, and receptor-binding domain in purple) and the nanobody (the… view more  Credit: Sicai Zhang/Dong Lab, Boston Children’s Hospital While rare, botulism can cause paralysis and is potentially fatal. It is caused by nerve-damaging toxins […]

Researchers discover new way to deliver DNA-based therapies for diseases

The above image shows cells illuminated by quinine (fluorescent blue) and green fluorescent protein. This allows the University of Minnesota researchers to—for the first time—observe how polymers interact with human cells when delivering medicines. The discovery could be used in advancing DNA and RNA-based treatments such as gene therapy and vaccines. Credit: Reineke Group and […]

Prototype tech shrinks AI to deliver brain-like functionality in one powerful device — ScienceDaily

Researchers have developed artificial intelligence technology that brings together imaging, processing, machine learning and memory in one electronic chip, powered by light. The prototype shrinks artificial intelligence technology by imitating the way that the human brain processes visual information. The nanoscale advance combines the core software needed to drive artificial intelligence with image-capturing hardware in […]

Researchers engineer tiny machines that deliver medicine efficiently

“Theragrippers” are inspired by a parasitic worm that clamps onto its host’s intestines. When an open theragripper is exposed to internal body temperatures, it closes on the intestinal wall. Image credit: John Hopkins University Inspired by a parasitic worm that digs its sharp teeth into its host’s intestines, Johns Hopkins researchers have designed tiny, star-shaped […]

Researchers engineer tiny machines that deliver medicine efficiently — ScienceDaily

Inspired by a parasitic worm that digs its sharp teeth into its host’s intestines, Johns Hopkins researchers have designed tiny, star-shaped microdevices that can latch onto intestinal mucosa and release drugs into the body. David Gracias, Ph.D., a professor in the Johns Hopkins University Whiting School of Engineering, and Johns Hopkins gastroenterologist Florin M. Selaru, […]