New method shows promise in identifying disease-fighting drug targets

Credit: Unsplash/CC0 Public Domain A new method of identifying molecular targets to fight disease could help accelerate future drug development new Griffith University research published in Scientific Reports has found. Professor Ron Quinn and Dr. Miaomiao Liu from the Griffith Institute for Drug Discovery have developed a way to identify the direct molecular target (usually […]

Skin Cell Atlas points to new drug targets for inflammatory diseases — ScienceDaily

Scientists have created a highly detailed map of skin, which reveals that cellular processes from development are re-activated in cells from patients with inflammatory skin disease. The researchers from the Wellcome Sanger Institute, Newcastle University and Kings College London, discovered that skin from eczema and psoriasis patients share many of the same molecular pathways as […]

Scientists identify contents of ancient Maya drug containers — ScienceDaily

Scientists have identified the presence of a non-tobacco plant in ancient Maya drug containers for the first time. The Washington State University researchers detected Mexican marigold (Tagetes lucida) in residues taken from 14 miniature Maya ceramic vessels. Originally buried more than 1,000 years ago on Mexico’s Yucatán peninsula, the vessels also contain chemical traces present […]

WSU scientists identify contents of ancient Maya drug containers

IMAGE: Frontal and lateral view of a Muna-type (AD 750-900) paneled flask with distinctive serrated-edge decoration. view more  Credit: WSU PULLMAN, Wash. – Scientists have identified the presence of a non-tobacco plant in ancient Maya drug containers for the first time. The Washington State University researchers detected Mexican marigold (Tagetes lucida) in residues taken from 14 […]

New virtual screening strategy identifies existing drug that inhibits Covid-19 virus

IMAGE: Colorized scanning electron micrograph of an apoptotic cell (pink) heavily infected with SARS-COV-2 virus particles (green), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF)… view more  Credit: National Institute of Allergy and Infectious Diseases/NIH, 2020 (CC0) A novel computational drug screening strategy combined with lab experiments suggest that pralatrexate, […]

New mutations in malaria parasite encourage resistance against key preventive drug

IMAGE: SEM of a mosquito (Anopheles stephensi) clearly showing the wing, proboscis, antennae, abdomen and legs. Anopheles stephensi is one of the major vectors of urban malaria in India and some… view more  Credit: Lauren Holden, Wellcome Collection (CC BY 4.0) In the ongoing arms race between humans and the parasite that causes malaria, Taane Clark […]

Protein twist and squeeze confers cancer drug resistance — ScienceDaily

In 1986, cellular biochemist Kazumitsu Ueda, currently at Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), discovered that a protein called ABCB1 could transport multiple chemotherapeutics out of some cancer cells, making them resistant to treatment. How it did this has remained a mystery for the past 35 years. Now, his team has published a […]

The Phase 3 clinical trial showed that the drug, called CC-486, significantly improved survival in older patients, over the age of 55, with AML — ScienceDaily

A landmark paper published today in the New England Journal of Medicine describes the results from a global trial across 148 sites in 23 countries, showing a 30 per cent improvement in survival in patients with acute myeloid leukemia (AML). The Phase 3 clinical trial called QUAZAR, showed that a drug, called CC-486, significantly improved […]