Cellulose nanofibril-based encapsulation structure to control drug release

The design of MPDA@GO/CNF encapsulation structure and the application for controlled drug release. Credit: LIU Yingying Intelligent hydrogels with multiple functions such as sustained drug release abilities with low burst release, antibacterial properties, and biocompatibility are highly desirable in the biomaterials fields, particularly for cellulose-based drug carriers. “Despite the nanocellulose-based hydrogels, which are promising for […]

Protein twist and squeeze confers cancer drug resistance

In 1986, cellular biochemist Kazumitsu Ueda, currently at Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), discovered that a protein called ABCB1 could transport multiple chemotherapeutics out of some cancer cells, making them resistant to treatment. How it did this has remained a mystery for the past 35 years. Now, his team has published a […]

HKU chemists develop a new drug discovery strategy for “undruggable” drug targets

IMAGE: Graphic illustration of the work: DNA-programmed affinity labelling (DPAL) enables the direct screening of DNA-encoded chemical libraries (DELs) against membrane protein targets on live cells to create novel drug discovery… view more  Credit: The University of Hong Kong A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, […]

New drug inhibits the growth of cancer cells

IMAGE: Cartoon representation of the POLRMT-Inhibitor complex. view more  Credit: Hauke S. Hillen A newly developed compound starves cancer cells by attacking their “power plants” – the so-called mitochondria. The new compound prevents the genetic information within mitochondria from being read. Researchers from the Max Planck Institute for Biology of Ageing in Cologne, the Karolinska Institute […]

Ludwig Cancer Research study reveals how ecDNA forms and drives cancer drug resistance

IMAGE: Ludwig San Diego Members Don Cleveland and Ofer Shoshani view more  Credit: Ludwig Cancer Research DECEMBER 23, 2020, NEW YORK – Researchers led by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the mystery of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, […]

Global trial reveals life saving drug for acute myeloid leukemia

A landmark paper published today in the New England Journal of Medicine describes the results from a global trial across 148 sites in 23 countries, showing a 30 per cent improvement in survival in patients with acute myeloid leukemia (AML).  The Phase 3 clinical trial called QUAZAR, showed that a drug, called CC-486, significantly improved […]

The pandemic has had a dramatic effect on drug overdoses

The early months of the pandemic (March to May 2020) saw a spike in overdose deaths. (Pexels/) The COVID-19 pandemic has overtaken the health news cycle this year. And though the novel coronavirus remains a major public health threat, other substantial health issues that affect Americans—like the opioid epidemic—haven’t gone away and many of them […]

New drug molecules hold promise for treating rare inherited terminal childhood disease

Scientists at the University of Exeter have identified a way to “rescue” cells that have genetically mutated, paving the way to a possible new treatment for rare terminal childhood illness such as mitochondrial disease. The research, funded by the United Mitochondrial Disease Foundation in the USA, was led by Professors Matt Whiteman and Tim Etheridge. […]

Blood pressure drug may be key to increasing lifespan, new study shows

IMAGE: Scientists found that C. elegans administered metolazone lived longer than those that were not given the drug. This suggests that metolazone, despite being an anti-hypertension drug, can be used in… view more  Credit: Eriko Kage-Nakadai, Osaka City University Since time immemorial, people have been fascinated by ways to stop aging. Nearly every culture has stories […]