Enzyme discovery can help rein in blood vessels that fuel cancer

LA JOLLA, CA–Most living things need oxygen to grow and thrive. Even cancerous tumors. That’s why tumors will readily sprout new blood vessels if their oxygen is starved, creating new lifelines for survival. A study published today from Scripps Research pinpoints the precise molecular machinery that makes this happen, providing scientific insights that can potentially […]

Researcher uses machine learning to demonstrate that DNA impacts cancer risk

Lifestyle, or put another way ‘bad habits’, is one of the textbook explanations for why some people are at higher risk for cancer. We often hear that smoking increases our risk of developing lung cancer or that a high-fat diet increases our risk of developing bowel cancer, but not all smokers get lung cancer and […]

Diversity, severity of autism symptoms linked to mutation locations

NEW YORK, NY (Dec. 22, 2020)–One of the most recognizable characteristics of autism is an amazing diversity of associated behavioral symptoms. Clinicians view autism as a broad spectrum of related disorders, and the origin of the disease’s heterogeneity has puzzled scientists, doctors, and affected families for decades. In a recent study, researchers at Columbia University […]

New mammal reference genome helps ID genetic variants for human health

The rhesus macaque is the most widely studied nonhuman primate in biomedical research. A genome sequencing project for this species, led by researchers at Baylor College of Medicine, the University of Missouri and the University of Washington, has created a new framework for study of this important primate. Research published in the journal Science has […]

Changing the perspective on the ‘Cinderella of the cytoskeleton’

SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell. When researchers discovered that SETD2 is mutated or lost in several cancer types, most commonly a type of kidney cancer called clear-cell renal cell carcinoma, all eyes […]

Light-controlled genes could reveal how gut bacteria impact health — ScienceDaily

Baylor College of Medicine researcher Meng Wang had already shown that bacteria that make a metabolite called colanic acid (CA) could extend the lifespan of worms in her lab by as much as 50%, but her collaboration with Rice University synthetic biologist Jeffrey Tabor is providing tools to answer the bigger question of how the […]

The incredible, variable bacteria living in your mouth

IMAGE: Micrograph showing Rothia cells (light blue) in their native habitat, a bacterial biofilm scraped from the human tongue. view more  Credit: Photo credit: Jessica Mark Welch, Marine Biological Laboratory. Bacteria often show very strong biogeography – some bacteria are abundant in specific locations while absent from others – leading to major questions when applying microbiology […]

Gene biomarkers indicate liver toxicity quickly and accurately

IMAGE: From left: University of Illinois researchers Zeynep Madak-Erdogan, associate professor of nutrition; Rohit Bhargava, director of the Cancer Center; and Colleen Bushell, director of the Healthcare Innovation Program Office at… view more  Credit: University of Illinois. URBANA, Ill. ¬- When agrochemical and pharmaceutical companies develop new products, they must test extensively for potential toxicity before […]

Study in mice shows genes may be altered through drug repurposing — ScienceDaily

Researchers at the University of Illinois Chicago have published a study showing a promising approach to using drug repurposing to treat genetic diseases. A team from the UIC Department of Ophthalmology and Visual Sciences published the article, “Gene dosage manipulation alleviates manifestations of hereditary PAX6 haploinsufficiency in mice” in the journal Science Translational Medicine. Nearly […]

Genes could be key to new COVID-19 treatments, study finds — ScienceDaily

Potential treatments for Covid-19 have been identified after the discovery of five genes associated with the most severe form of the disease. Genetic evidence is second only to clinical trials as a way to tell which treatments will be effective in a disease. Existing drugs that target the actions of the genes reveal which drugs […]