An explanation for the lack of blood oxygenation detected in many COVID-19 patients

One of the physiopathological characteristics of COVID-19 that has most baffled the scientific and medical community is what is known as “silent hypoxemia” or “happy hypoxia”. Patients suffering this phenomenon, the causes of which are still unknown, have severe pneumonia with markedly decreased arterial blood oxygen levels (known as hypoxemia). However, they do not report […]

Discovery of aging mechanism for hematopoietic stem cells

IMAGE: No caption view more  Credit: ©Atsushi IWAMA, The Institute of Medical Science, The University of Tokyo By transferring mouse aged hematopoietic stem cells (aged HSCs, *1) to the environment of young mice (bone marrow niche, *2), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem […]

Venetoclax added to standard treatments shows promise in high-risk myeloid blood cancers

IMAGE: Jacqueline Garcia, MD view more  Credit: Dana-Farber Cancer Institute The novel oral drug venetoclax can be safely added to standard therapies for some high-risk myeloid blood cancers and in early studies the combination shows promise of improved outcomes, say scientists from Dana-Farber Cancer Institute. Venetoclax targets cancer’s survival proteins, making them more vulnerable to treatments […]

CAR T-cell therapy found highly effective in patients with high-risk non-Hodgkin lymphoma

A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial, Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting. While NHL tends to be a slow-growing disease, […]

Study reveals surprising benefit of clonal hematopoiesis in allogeneic transplants

IMAGE: Christopher Gibson, MD view more  Credit: Dana-Farber Cancer Institute Clonal hematopoiesis (CH) is a recently identified condition in which mutations associated with blood cancers are detected in the blood of some healthy, usually older, individuals who don’t have cancer. People with CH, while asymptomatic, have an elevated risk of developing blood cancers and other negative […]

Donor stem cell transplant shown to improve survival in older patients with MDS

IMAGE: Corey Cutler, MD, MPH, FRCPC view more  Credit: Dana-Farber Cancer Institute A new clinical trial offers the most compelling evidence to date that a donor stem cell transplant can improve survival rates for older patients with higher-risk myelodysplastic syndrome (MDS), Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual […]

Iron infusion proves effective to treat anaemia in Rural Africa

IMAGE: Iron infusions help reduce iron-deficiency anaemia in low-income settings. view more  Credit: Danielle Powell, Swiss TPH Over 1 billion people globally are affected by iron-deficiency anaemia. In sub-Saharan Africa, anaemia is a major public health concern with roughly 60% of the population suffering from anaemia. Around half of those cases are due to iron deficiency. […]

Survival protein may prevent collateral damage during cancer therapy

IMAGE: The cell survival protein BCL-XL may protect kidneys from damage caused by cancer therapies. view more  Credit: WEHI, Australia Australian researchers have identified a protein that could protect the kidneys from ‘bystander’ damage caused by cancer therapies. The ‘cell survival protein’, called BCL-XL, was required in laboratory models to keep kidney cells alive and […]

Poverty linked to higher risk of death in children with cancer undergoing transplant

Despite the increasing use and promise of hematopoietic cell transplantation (HCT) as curative therapy for children with cancer and other life-threatening diseases, new research suggests that children transplanted for cancer are more likely to die from treatment-related complications if they live in poorer neighborhoods. The study, published today in the journal Blood, also found that […]