Skin Cell Atlas points to new drug targets for inflammatory diseases — ScienceDaily

Scientists have created a highly detailed map of skin, which reveals that cellular processes from development are re-activated in cells from patients with inflammatory skin disease. The researchers from the Wellcome Sanger Institute, Newcastle University and Kings College London, discovered that skin from eczema and psoriasis patients share many of the same molecular pathways as […]

Multi-population risk scores could improve risk prediction for inflammatory bowel diseases, study finds

Using genetic data from nearly 30,000 people, Mount Sinai researchers have built risk scores from a combination of datasets representing distinct ancestral populations that improve prediction of risk for inflammatory bowel diseases (IBD) including Crohn’s disease and ulcerative colitis. The study was published in Gastroenterology on December 24. The researchers found that polygenic risk scores, […]

Pitt scientists identify genetic risks of rare inflammatory disease

IMAGE: Professor of pediatrics and medicine, University of Pittsburgh, and chief, Division of Pediatric Rheumatology, UPMC Children’s Hospital of Pittsburgh. view more  Credit: UPMC PITTSBURGH, Dec. 11, 2020 – In a paper published today in the American Journal of Human Genetics, a group of international collaborators led by researchers from the University of Pittsburgh School of […]

People with inflammatory bowel disease still die earlier despite increase in life

A study comparing life expectancy of people with inflammatory bowel disease (IBD) and without found that, while life expectancy increased for both groups, people with IBD generally died sooner. The study is published in CMAJ (Canadian Medical Association Journal). “The good news is life expectancy has increased in people with IBD, but there is still […]

Study used a ‘search the genome’ approach to reveal how mutations in a gene called UBA1 are associated with inflammatory diseases — ScienceDaily

Researchers from the National Institutes of Health (NIH) have discovered a new inflammatory disorder called vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic syndrome (VEXAS), which is caused by mutations in the UBA1 gene. VEXAS causes symptoms that included blood clots in veins, recurrent fevers, pulmonary abnormalities and vacuoles (unusual cavity-like structures) in myeloid cells. The […]

Oncotarget: Evaluation of cellular alteration & inflammatory profile of cells

IMAGE: Percentage of apoptosis in PMC, A549 and/or MCF7 after 24 hours exposed to talc. PMC = pleural mesothelial cells; NC = neoplastic cells. *p view more  Credit: Correspondence to – Milena Marques Pagliarelli Acencio – [email protected] Oncotarget recently published “Evaluation of cellular alterations and inflammatory profile of mesothelial cells and/or neoplastic cells exposed to talc […]