Ion beam breeding to the rescue — ScienceDaily

A research team led by scientists at the RIKEN Nishina Center for Accelerator-Based Science (RNC) has successfully created larger-than-usual strains of zooplankton — which are used in fish nurseries — by creating mutations with a heavy ion beam. The new strains of zooplankton could contribute to improving the survival rate and optimizing the growth of […]

Understanding ion channel inhibition to open doors in drug discovery

The structure of the tetrameric structure of a TRPC5 channel in complex with Pico145 (left). Each TRPC5 monomer is displayed in a different colour. The structure revealed that the drug-like small molecule Pico145 can bind to each of four pockets between subunits (middle). When the structure of TRPC5 was determined in the absence of Pico145, […]

Pharmacology – An unconventional ion channel

Scientists at Ludwig-Maximilians-Universitaet (LMU) in Munich have identified the first mechanosensitive ion channel to be found in an intracellular vesicle system. It responds to concentration changes within the vesicle, and probably controls the initiation of immune reactions. Small membrane vesicles, known as endosomes or lysosomes play a key role in the uptake, secretion and intracellular […]