New humanized mouse model provides insight into immunotherapy resistance

IMAGE: Dr. Rajasekharan Somasundaram view more  Credit: The Wistar Institute PHILADELPHIA — (Jan. 12, 2021) — Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells. These findings were published […]

SARS-CoV-2 infection demonstrated in a human lung bronchioalveolar tissue model

Heidelberg/Germany, 11 January 2021 – Development of an in vitro human-derived tissue model for studying virus infection and disease progression in the alveolar cells of the lungs responsible for oxygen and carbon dioxide exchange with the blood might enable the study of possible therapies for acute respiratory distress syndrome (ARDS) triggered by SARS-CoV-2. Researchers in […]

Gene therapy strategy found effective in mouse model of hereditary disease TSC

BOSTON – Patients with tuberous sclerosis complex, a genetic disorder characterized by the growth of noncancerous tumors in multiple organs of the body, have limited treatment options. A team led by investigators at Massachusetts General Hospital (MGH) has now shown that gene therapy can effectively treat mice that express one of the mutated genes that […]

Results of comprehensive SARS-CoV-2 animal model study published in Nature Microbiology

San Antonio, Texas (January 4, 2020) – Scientists at Texas Biomedical Research Institute (Texas Biomed) and Southwest National Primate Research Center (SNPRC) published their findings regarding a comprehensive animal model study of SARS-CoV-2 in the peer-reviewed journal Nature Microbiology. These findings were originally posted online in BioRxiv in June of 2020. The study evaluated three […]

Scientists find the error source of a sea-ice model varies with the season

IMAGE: Schematic diagram of the sea-ice simulation error sources of a regional configuration of MITgcm. view more  Credit: Yue Sun Arctic sea ice has been rapidly declining in recent decades, and changes in arctic sea ice can have a significant impact on global weather and climate through interactions with the atmosphere and oceans. In addition, the […]

Researchers measure, model desalination membranes to maximize flow, clean more water

IMAGE: This 3D model of a polymer desalination membrane shows water flow — the silver channels, moving from top to bottom — avoiding dense spots in the membrane and slowing flow. view more  Credit: Image by the Ganapathysubramanian research group/Iowa State University and Gregory Foss/Texas Advanced Computing Center. AMES, Iowa – Nature has figured out how […]