‘You say tomato, I say genomics’: Genome sequences for two wild tomato ancestors

IMAGE: Two wild ancestors of tomato (SP: Solanum pimpinellifolium, SLC: Solanum lycopersicum var. cerasiforme) view more  Credit: University of Tsukuba Tsukuba, Japan – Tomatoes are one of the most popular types of fresh produce consumed worldwide, as well as being an important ingredient in many manufactured foods. As with other cultivated crops, some potentially useful genes […]

University of Cincinnati research unveils possible new combo therapy for head and neck cancer

IMAGE: Christina Wicker, Ph.D., a postdoctoral fellow in the lab of Vinita Takiar, MD, Ph.D., led this research, published in Cancer Letters, which she says will hopefully extend the lives of… view more  Credit: Colleen Kelley/University of Cincinnati Head and neck cancer is the sixth most common cancer worldwide, and while effective treatments exist, sadly, the […]

Regulating the ribosomal RNA production line

IMAGE: A new cryo-EM study shows that the enzyme that makes RNA from a DNA template (RNA polymerase) is altered to slow the production of ribosomal RNA in the bacteria E…. view more  Credit: Murakami Laboratory, Penn State The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA […]

New variety of paintbrush lily developed by a novel plant tissue culture technique

IMAGE: The steps involved in generating triploid and hexaploid plants by endosperm culture (Photos: Arisa Nakano, Masahiro Mii, Yoichiro Hoshino). view more  Credit: Arisa Nakano, Masahiro Mii, Yoichiro Hoshino Scientists at Hokkaido University and Chiba University have developed simultaneous triploid and hexaploid varieties of Haemanthus albiflos by the application of endosperm culture, thus extending the use […]

Botulism breakthrough? Taming botulinum toxin to deliver therapeutics

IMAGE: The toxin-based delivery platform consists of the modified botulinum toxin at upper left (protease domain in gold, translocation domain in blue, and receptor-binding domain in purple) and the nanobody (the… view more  Credit: Sicai Zhang/Dong Lab, Boston Children’s Hospital While rare, botulism can cause paralysis and is potentially fatal. It is caused by nerve-damaging toxins […]

Bioenergetics: New features of ATP synthase

The mitochondrial ATP synthase is energy-converting macromolecular machine that uses the electrochemical potential across the bioenergetic membrane called cristae. This potential is maintained via a membrane curvature that is induced by ATP synthase assembled in dimers. The dimers shaping the bioenergetic membrane were thought to be universal across the eukaryotic organisms. Two newly published cryo-EM […]

Integrator: A guardian of the human transcriptome

IMAGE: RNA polymerase II (RNAPII) initiates transcription at a multitude of positions in the human genome. However, only a fraction of these sites is associated with genes that give rise to… view more  Credit: Søren Lykkke-Andersen In a joint collaboration, Danish and German researchers have characterized a cellular activity that protects our cells from potentially toxic […]

Study explains why patients with cancer spread to the liver have worse outcomes

IMAGE: Weiping Zou, M.D., Ph.D. view more  Credit: University of Michigan Rogel Cancer Center ANN ARBOR, Michigan — Michael Green, M.D., Ph.D., noticed that when his patients had cancer that spread to the liver, they fared poorly – more so than when cancer spread to other parts of the body. Not only that, but transformative immunotherapy […]

Gut cells sound the alarm when parasites invade

To effectively combat an infection, the body first has to sense it’s been invaded, then the affected tissue must send out signals to corral resources to fight the intruder. Knowing more about these early stages of pathogen recognition and response may provide scientists with crucial clues when it comes to preventing infections or treating inflammatory […]

The liverwort oil body is formed by redirection of the secretory pathway

Cells, the basic unit of life, are surrounded by a limiting membrane called the plasma membrane. Inside cells, there are various membrane-bounded organelles, each of which has various and distinctive functions. How these organelles, which individually boast different functions, have been developed during evolution remains unknown. This phenomenon has fascinated many researchers. In the study […]