New mutations in malaria parasite encourage resistance against key preventive drug

IMAGE: SEM of a mosquito (Anopheles stephensi) clearly showing the wing, proboscis, antennae, abdomen and legs. Anopheles stephensi is one of the major vectors of urban malaria in India and some… view more  Credit: Lauren Holden, Wellcome Collection (CC BY 4.0) In the ongoing arms race between humans and the parasite that causes malaria, Taane Clark […]

Understanding COVID-19 infection and possible mutations — ScienceDaily

The binding of a SARS-CoV-2 virus surface protein spike — a projection from the spherical virus particle — to the human cell surface protein ACE2 is the first step to infection that may lead to COVID-19 disease. Penn State researchers computationally assessed how changes to the virus spike makeup can affect binding with ACE2 and […]

Native American ancestry associated with more mutations in EGFR gene among Latin Americans

Bottom Line: Among patients with lung cancer from Latin America, genomic and ancestry analyses revealed that Native American ancestry was associated with increased mutations in the EGFR gene, independent of smoking status. Journal in Which the Study was Published: Cancer Discovery, a journal of the American Association for Cancer Research Author: Matthew Meyerson, MD, PhD, […]

SARS-CoV-2 mutations do not appear to increase transmissibility — ScienceDaily

None of the mutations currently documented in the SARS-CoV-2 virus appear to increase its transmissibility in humans, according to a study led by UCL researchers. The analysis of virus genomes from over 46,000 people with COVID-19 from 99 countries is published today in Nature Communications. First and corresponding author Dr Lucy van Dorp (UCL Genetics […]

SARS-CoV-2 mutations do not appear to increase transmissibility

None of the mutations currently documented in the SARS-CoV-2 virus appear to increase its transmissibility in humans, according to a study led by UCL researchers. The analysis of virus genomes from over 46,000 people with COVID-19 from 99 countries is published today in Nature Communications. First and corresponding author Dr Lucy van Dorp (UCL Genetics […]

Study used a ‘search the genome’ approach to reveal how mutations in a gene called UBA1 are associated with inflammatory diseases — ScienceDaily

Researchers from the National Institutes of Health (NIH) have discovered a new inflammatory disorder called vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic syndrome (VEXAS), which is caused by mutations in the UBA1 gene. VEXAS causes symptoms that included blood clots in veins, recurrent fevers, pulmonary abnormalities and vacuoles (unusual cavity-like structures) in myeloid cells. The […]