A new strategy for siRNA stabilization by an artificial cationic oligosaccharide

IMAGE: ODAGal4 strongly stabilises duplex structures of siRNAs, particularly nucleotides with phosphorothioate linkages, and prevents degradation of the RNAs. view more  Credit: TMIMS RNA interference is a gene regulatory mechanism in which the expression of specific genes is downregulated by endogenous microRNAs or by small interfering RNAs (siRNAs). Although siRNAs have broad potential for gene-silencing therapy, […]