Genome-editing tool TALEN outperforms CRISPR-Cas9 in tightly packed DNA — ScienceDaily

Researchers used single-molecule imaging to compare the genome-editing tools CRISPR-Cas9 and TALEN. Their experiments revealed that TALEN is up to five times more efficient than CRISPR-Cas9 in parts of the genome, called heterochromatin, that are densely packed. Fragile X syndrome, sickle cell anemia, beta-thalassemia and other diseases are the result of genetic defects in the […]

Genome-editing tool TALEN outperforms CRISPR-Cas9 in tightly packed DNA

Credit: CC0 Public Domain Researchers used single-molecule imaging to compare the genome-editing tools CRISPR-Cas9 and TALEN. Their experiments revealed that TALEN is up to five times more efficient than CRISPR-Cas9 in parts of the genome, called heterochromatin, that are densely packed. Fragile X syndrome, sickle cell anemia, beta-thalassemia and other diseases are the result of […]

The body fires ‘blobs of fat’ packed with toxic proteins to fight bacteria

The human body uses many tactics to fight invaders. Scientists just found another weapon in its arsenal: tiny fat blobs packed with toxic proteins that are fired at the enemy.  Complex organisms including fungi, plants and animals are made up of eukaryotic cells that contain subcellular structures called organelles. These organelles all work together to […]