Synthesis of potent antibiotic follows unusual chemical pathway — ScienceDaily

Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic’s synthesis. The improved understanding of the chemistry behind this process, detailed in a new study led by Penn State chemists, could allow researchers to adapt this and similar compounds for use in human medicine. “The antibiotic thiostrepton […]

Synthesis of potent antibiotic follows unusual chemical pathway

The synthesis of the potent antibiotic thiostrepton uses a radical SAM protein TsrM, whose crystal structure is shown at left while bound to an iron-sulfur cluster and cobalamin. New images of this crystal structure allowed researchers from Penn State to infer the chemical steps during the antibiotic’s synthesis (right), as a methyl group moves from […]

The liverwort oil body is formed by redirection of the secretory pathway

Cells, the basic unit of life, are surrounded by a limiting membrane called the plasma membrane. Inside cells, there are various membrane-bounded organelles, each of which has various and distinctive functions. How these organelles, which individually boast different functions, have been developed during evolution remains unknown. This phenomenon has fascinated many researchers. In the study […]

The liverwort oil body is formed by redirection of the secretory pathway

An oil body in a cell of the liverwort, Marchantia polymorpha. Credit: NIBB Cells, the basic unit of life, are surrounded by a limiting membrane called the plasma membrane. Inside cells, there are various membrane-bounded organelles, each of which has various and distinctive functions. How these organelles, which individually boast different functions, have been developed […]

Dual-acting immuno-antibiotics block an essential pathway in bacteria and activate the adaptive immune response — ScienceDaily

Wistar Institute scientists have discovered a new class of compounds that uniquely combine direct antibiotic killing of pan drug-resistant bacterial pathogens with a simultaneous rapid immune response for combatting antimicrobial resistance (AMR). These finding were published today in Nature. The World Health Organization (WHO) has declared AMR as one of the top 10 global public […]

New insight into a placental gene pathway and its association with vitamin D — ScienceDaily

According to the World Health Organization, preeclampsia affects between 2% to 8% of pregnancies. It can cause serious, sometimes fatal, complications in the mother and child. Among other risk factors, such as obesity and diabetes, vitamin D deficiency during pregnancy has been associated with an increased risk of preeclampsia. In an article in Pregnancy Hypertension, […]

Extrafollicular B cell pathway — ScienceDaily

In severe cases of COVID-19, Emory researchers have been observing an exuberant activation of immune cells, resembling acute flares of systemic lupus erythematosus (SLE), an autoimmune disease. Their findings point towards tests that could separate some COVID-19 patients who need immune-calming therapies from others who may not. They also may begin to explain why some […]