Botulism breakthrough? Taming botulinum toxin to deliver therapeutics

IMAGE: The toxin-based delivery platform consists of the modified botulinum toxin at upper left (protease domain in gold, translocation domain in blue, and receptor-binding domain in purple) and the nanobody (the… view more  Credit: Sicai Zhang/Dong Lab, Boston Children’s Hospital While rare, botulism can cause paralysis and is potentially fatal. It is caused by nerve-damaging toxins […]

Hydroxychloroquine blood levels predict clotting risk in patients with lupus

The antimalarial drug hydroxychloroquine is frequently prescribed to treat symptoms of the autoimmune disease lupus. In addition to decreasing disease flares, the drug can also prevent blood clots, which are a major problem in individuals with lupus. A new study in Arthritis & Rheumatology shows that monitoring patients’ blood levels of hydroxychloroquine can predict their […]

LSU Health New Orleans discovers potential new RX strategy for stroke

New Orleans, LA – Research conducted at LSU Health New Orleans Neuroscience Center of Excellence reports that a combination of an LSU Health-patented drug and selected DHA derivatives is more effective in protecting brain cells and increasing recovery after stroke than a single drug. The findings are published in Brain Circulation, available here. Nicolas Bazan, […]

Blood pressure drug may be key to increasing lifespan, new study shows

IMAGE: Scientists found that C. elegans administered metolazone lived longer than those that were not given the drug. This suggests that metolazone, despite being an anti-hypertension drug, can be used in… view more  Credit: Eriko Kage-Nakadai, Osaka City University Since time immemorial, people have been fascinated by ways to stop aging. Nearly every culture has stories […]

Researchers call for clarity on the definition of medicine misuse

Medicine misuse is a public health issue, but the term has different meanings to people in different settings. A recent analysis of published studies provides a comprehensive overview of the terms and definitions used to characterize medicine misuse. The findings are published in the British Journal of Clinical Pharmacology. Among 51 relevant studies, there were […]

Cholesterol medications linked to lower cancer-related deaths in women

Among women with breast cancer, colorectal cancer, or melanoma, those who were taking cholesterol-lowering medications, were less likely to die from cancer, according to an analysis published in the British Journal of Clinical Pharmacology. The analysis included 20,046,11,719 and 6,430 women in Australia who were diagnosed with breast cancer, colorectal cancer, and melanoma, respectively, from […]

A new strategy for siRNA stabilization by an artificial cationic oligosaccharide

IMAGE: ODAGal4 strongly stabilises duplex structures of siRNAs, particularly nucleotides with phosphorothioate linkages, and prevents degradation of the RNAs. view more  Credit: TMIMS RNA interference is a gene regulatory mechanism in which the expression of specific genes is downregulated by endogenous microRNAs or by small interfering RNAs (siRNAs). Although siRNAs have broad potential for gene-silencing therapy, […]