Botulism breakthrough? Taming botulinum toxin to deliver therapeutics

IMAGE: The toxin-based delivery platform consists of the modified botulinum toxin at upper left (protease domain in gold, translocation domain in blue, and receptor-binding domain in purple) and the nanobody (the… view more  Credit: Sicai Zhang/Dong Lab, Boston Children’s Hospital While rare, botulism can cause paralysis and is potentially fatal. It is caused by nerve-damaging toxins […]

Hydroxychloroquine blood levels predict clotting risk in patients with lupus

The antimalarial drug hydroxychloroquine is frequently prescribed to treat symptoms of the autoimmune disease lupus. In addition to decreasing disease flares, the drug can also prevent blood clots, which are a major problem in individuals with lupus. A new study in Arthritis & Rheumatology shows that monitoring patients’ blood levels of hydroxychloroquine can predict their […]

Quick look under the skin

IMAGE: First author Oliver Schoppe in the Center for Translational Cancer Research at the Technical University of Munich. view more  Credit: Astrid Eckert / TUM Imaging techniques enable a detailed look inside an organism. But interpreting the data is time-consuming and requires a great deal of experience. Artificial neural networks open up new possibilities: They require […]

UC researcher urges caution using remdesivir to treat COVID-19

IMAGE: Bingfang Yan is a professor at the University of Cincinnati’s James L. Winkle College of Pharmacy. Yan’s UC laboratory studies how drugs are metabolized in the body to see if… view more  Credit: University of Cincinnati While the world has its eyes on vaccines to stop the spread of coronavirus, therapeutics are still necessary to […]

Traditional Ghanaian medicines show promise against tropical diseases

IMAGE: Chemical and Biological Investigation of Traditional medicines for Activity against NTDs. Photo of Schistosomiasis and Onchocerciasis sourced from Centers for Disease Control and Prevention DPDx – Laboratory Identification of Parasites of… view more  Credit: Osei-Safo 2020 (CC-BY 2.0) The discovery of new drugs is vital to achieving the eradication of neglected tropical diseases (NTDs) in […]

New mutations in malaria parasite encourage resistance against key preventive drug

IMAGE: SEM of a mosquito (Anopheles stephensi) clearly showing the wing, proboscis, antennae, abdomen and legs. Anopheles stephensi is one of the major vectors of urban malaria in India and some… view more  Credit: Lauren Holden, Wellcome Collection (CC BY 4.0) In the ongoing arms race between humans and the parasite that causes malaria, Taane Clark […]

Stopping RAS inhibitors tied to worse outcomes in patients with chronic kidney disease

IMAGE: Principal investigator Juan Jesus Carrero, professor at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet in Sweden. view more  Credit: Ulf Sirborn. Small studies have suggested that a group of medications called RAS inhibitors may be harmful in persons with advanced chronic kidney disease, and physicians therefore often stop the treatment in such […]

With COVID exacerbating superbug threat, researchers ID new weapon

IMAGE: Corrie Detweiler in the lab at CU Boulder. view more  Credit: CU Boulder As scientists around the globe wage war against a novel, deadly virus, one University of Colorado Boulder lab is working on new weapons to battle a different microbial threat: a rising tide of antibiotic-resistant bacteria which, if left unchecked, could kill an […]

Genetic engineering without unwanted side effects helps fight parasites

Around a third of the world’s population carries Toxoplasma gondii, a parasite that puts people with a weakened immune system at risk and can trigger malformations in the womb. The single-celled pathogen also leads to economic losses in agriculture, with toxoplasmosis increasing the risk of abortion among sheep, for example. The parasite has a complex […]

Blood pressure drug may be key to increasing lifespan, new study shows

IMAGE: Scientists found that C. elegans administered metolazone lived longer than those that were not given the drug. This suggests that metolazone, despite being an anti-hypertension drug, can be used in… view more  Credit: Eriko Kage-Nakadai, Osaka City University Since time immemorial, people have been fascinated by ways to stop aging. Nearly every culture has stories […]