Highly specific synaptic plasticity in addiction

IMAGE: One step of the methodology used to isolate and measure the MMP activity. view more  Credit: Elsevier Philadelphia, January 26, 2021 – Addiction, or substance use disorder (SUD), is a complex neurological condition that includes drug-seeking behavior among other cognitive, emotional and behavioral features. Synaptic plasticity, or changes in the way neurons communicate with one […]

Astrocytes eat connections to maintain plasticity in adult brains — ScienceDaily

Developing brains constantly sprout new neuronal connections called synapses as they learn and remember. Important connections — the ones that are repeatedly introduced, such as how to avoid danger — are nurtured and reinforced, while connections deemed unnecessary are pruned away. Adult brains undergo similar pruning, but it was unclear how or why synapses in […]

Astrocytes eat connections to maintain plasticity in adult brains

IMAGE: A 3-D animated image showing our synapse phagocytosis reporter in mouse hippocampus. Presynapses in green, astrocytes in white, and microglia in blue. Phagocytosed presynapses by glia were shown in red…. view more  Credit: KAIST Developing brains constantly sprout new neuronal connections called synapses as they learn and remember. Important connections — the ones that are […]