New method shows promise in identifying disease-fighting drug targets

Credit: Unsplash/CC0 Public Domain A new method of identifying molecular targets to fight disease could help accelerate future drug development new Griffith University research published in Scientific Reports has found. Professor Ron Quinn and Dr. Miaomiao Liu from the Griffith Institute for Drug Discovery have developed a way to identify the direct molecular target (usually […]

Combination treatment for methamphetamine use disorder shows promise — ScienceDaily

A combination of two medications, injectable naltrexone and oral bupropion, was safe and effective in treating adults with moderate or severe methamphetamine use disorder in a double-blind, placebo-controlled Phase III clinical trial. The findings suggest this combination therapy may be a promising addition to current approaches to treatment, such as cognitive behavioral therapy and contingency […]

Traditional Ghanaian medicines show promise against tropical diseases

IMAGE: Chemical and Biological Investigation of Traditional medicines for Activity against NTDs. Photo of Schistosomiasis and Onchocerciasis sourced from Centers for Disease Control and Prevention DPDx – Laboratory Identification of Parasites of… view more  Credit: Osei-Safo 2020 (CC-BY 2.0) The discovery of new drugs is vital to achieving the eradication of neglected tropical diseases (NTDs) in […]

Traditional Ghanaian medicines show promise against tropical diseases — ScienceDaily

The discovery of new drugs is vital to achieving the eradication of neglected tropical diseases (NTDs) in Africa and around the world. Now, researchers reporting in PLOS Neglected Tropical Diseases have identified traditional Ghanaian medicines which work in the lab against schistosomiasis, onchocerciasis and lymphatic filariasis, three diseases endemic to Ghana. The major intervention for […]

New drug molecules hold promise for treating rare inherited terminal childhood disease

Scientists at the University of Exeter have identified a way to “rescue” cells that have genetically mutated, paving the way to a possible new treatment for rare terminal childhood illness such as mitochondrial disease. The research, funded by the United Mitochondrial Disease Foundation in the USA, was led by Professors Matt Whiteman and Tim Etheridge. […]

50 years ago, urea showed promise as a sickle-cell treatment

a microscopic image showing the sickle curved shape of blood cells

Urea normalizes cells – Science News, December 19, 1970 Intravenous infusions of urea now appear to promise successful treatment of sickle-cell patients.… Urea causes sickled cells to revert to their normal, doughnut shape. Thus far, intravenous infusions of urea have relieved sickle-cell crises in 22 patients tested. Update Sickle-cell disease causes painful clots that can […]

AI model shows promise to generate faster, more accurate weather forecasts — ScienceDaily

Today’s weather forecasts come from some of the most powerful computers on Earth. The huge machines churn through millions of calculations to solve equations to predict temperature, wind, rainfall and other weather events. A forecast’s combined need for speed and accuracy taxes even the most modern computers. The future could take a radically different approach. […]

Molecule holds promise to reprogram white blood cells for better cancer treatment

IMAGE: Pictured L-R: Caitlin Brandle, research assistant, Dr. Gang Zhou, Timothy Kim, undergraduate student, Nada S. Aboelella, PhD, graduate student, Dr. Zhi-Chun Ding, assistant professor view more  Credit: Kim Ratliff, AU photographer Cancer immunotherapy using “designer” immune cells has revolutionized cancer treatment in recent years. In this type of therapy, T cells, a type of white […]

Single-crystal technology holds promise for next-generation lithium-ion batteries — ScienceDaily

A promising technology under development by major battery makers has become even more attractive, thanks to researchers who have taken an unprecedented look at one key barrier to better, longer-lasting lithium-ion batteries. Scientists at the U.S. Department of Energy’s Pacific Northwest National Laboratory report new findings about how to make a single-crystal, nickel-rich cathode hardier […]

Venetoclax added to standard treatments shows promise in high-risk myeloid blood cancers

IMAGE: Jacqueline Garcia, MD view more  Credit: Dana-Farber Cancer Institute The novel oral drug venetoclax can be safely added to standard therapies for some high-risk myeloid blood cancers and in early studies the combination shows promise of improved outcomes, say scientists from Dana-Farber Cancer Institute. Venetoclax targets cancer’s survival proteins, making them more vulnerable to treatments […]