Phages help reverse antibiotic resistance in dangerous superbug

Scientists investigated phages that can kill the world’s leading superbug, Acinetobacter baumannii, which is responsible for up to 20% of infections in intensive care units. Acinetobacter; Image credit: CDC A major risk of being hospitalized is catching a bacterial infection. Hospitals, especially areas including intensive care units and surgical wards, are teeming with bacteria, some […]

New humanized mouse model provides insight into immunotherapy resistance

IMAGE: Dr. Rajasekharan Somasundaram view more  Credit: The Wistar Institute PHILADELPHIA — (Jan. 12, 2021) — Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells. These findings were published […]

Antibiotic resistance from random DNA sequences — ScienceDaily

An important and still unanswered question is how new genes that cause antibiotic resistance arise. In a new study, Swedish and American researchers have shown how new genes that produce resistance can arise from completely random DNA sequences. The results have been published in the journal PLOS Genetics. Antibiotic resistance is a major global problem […]

Ferroptosis resistance in cancer: An emerging crisis of new hope

Announcing a new publication for BIO Integration journal. In this opinion article the authors Daiyun Xu, Yonghui Lü, Yongxiao Li, Shengbin Li, Zhe Wang and Junqing Wang from Sun Yat-Sen University, Guangzhou, China discuss ferroptosis resistance in cancer. Ferroptosis is a lethal consequence of accumulated lipid peroxidation catalyzed by ferrous iron and oxygen. This unique […]

New mutations in malaria parasite encourage resistance against key preventive drug

IMAGE: SEM of a mosquito (Anopheles stephensi) clearly showing the wing, proboscis, antennae, abdomen and legs. Anopheles stephensi is one of the major vectors of urban malaria in India and some… view more  Credit: Lauren Holden, Wellcome Collection (CC BY 4.0) In the ongoing arms race between humans and the parasite that causes malaria, Taane Clark […]

Protein twist and squeeze confers cancer drug resistance — ScienceDaily

In 1986, cellular biochemist Kazumitsu Ueda, currently at Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), discovered that a protein called ABCB1 could transport multiple chemotherapeutics out of some cancer cells, making them resistant to treatment. How it did this has remained a mystery for the past 35 years. Now, his team has published a […]

The puzzle of nonhost resistance: why do pathogens harm some plants but not others?

IMAGE: Ralph Panstruga & Matthew Moscou view more  Credit: Ralph Panstruga & Matthew Moscou People have puzzled for years why pathogen Phytophthora infestens causes the devastating late blight disease, source of the Irish Potato famine, on potatoes, but has no effect at all on plants like apple or cucumber. How are apple trees and cucumber plants […]

Protein twist and squeeze confers cancer drug resistance

In 1986, cellular biochemist Kazumitsu Ueda, currently at Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), discovered that a protein called ABCB1 could transport multiple chemotherapeutics out of some cancer cells, making them resistant to treatment. How it did this has remained a mystery for the past 35 years. Now, his team has published a […]

Ludwig Cancer Research study reveals how ecDNA forms and drives cancer drug resistance

IMAGE: Ludwig San Diego Members Don Cleveland and Ofer Shoshani view more  Credit: Ludwig Cancer Research DECEMBER 23, 2020, NEW YORK – Researchers led by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the mystery of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, […]