Regulating the ribosomal RNA production line — ScienceDaily

The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the most abundant type of RNA within cells, when resources are scarce and the bacteria Escherichia coli needs to slow its growth. Researchers used cryo-electron microscopy (cryo-EM) to capture the structures of the RNA polymerase while […]

Regulating the ribosomal RNA production line

IMAGE: A new cryo-EM study shows that the enzyme that makes RNA from a DNA template (RNA polymerase) is altered to slow the production of ribosomal RNA in the bacteria E…. view more  Credit: Murakami Laboratory, Penn State The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA […]

RNA ties itself in knots, then unties itself in mesmerizing video

Striking new videos show how RNA — the genetic molecule that tells cells how to build proteins — tangles up in insane knots as it forms, only to disentangle itself at the last second, and in a way that took scientists by surprise.  The high-resolution videos depict a bouncing conga line of nucleotides, the building […]

New videos show RNA as it’s never been seen

A new Northwestern University-led study is unfolding the mystery of how RNA molecules fold themselves to fit inside cells and perform specific functions. The findings could potentially break down a barrier to understanding and developing treatments for RNA-related diseases, including spinal muscular atrophy and perhaps even the novel coronavirus. “RNA folding is a dynamic process […]

Novel RNA factors may help cancer cells thrive

Like Peter Pan, some cells never grow up. In cancer, undifferentiated stem cells may help tumors such as glioblastoma become more aggressive than other forms of the disease. Certain groups of genes are supposed to help cells along the path to maturity, leaving their youthful “stemness” behind. This requires sweeping changes in the microRNAome — […]

Circular RNA regulates neuronal differentiation by scaffolding an inhibitory transcription complex — ScienceDaily

In a screening for a functional impact to the neuronal differentiation process, Danish researchers identified a specific circular RNA, circZNF827, which surprisingly “taps the brake” on neurogenesis. The results provide an interesting example of co-evolution of a circRNA, and its host-encoded protein product, that regulate each other’s function, to directly impact the fundamental process of […]

What is RNA? | Live Science

More than just DNA’s lesser-known cousin, RNA plays a central role in turning genetic information into your body’s proteins. This remarkable molecule also carries the genetic instructions for many viruses, and it may have helped life get its start. ‘Central Dogma’ Together, RNA, short for ribonucleic acid, and DNA, short for deoxyribonucleic acid, make up […]