Point-of-care test developed for tumor marker in human saliva based on lanthanide nanoprobes

Schematic illustration of CEA detection in saliva. Eu2O3 NCs and disposable syringe filter equipped with nitrocellulose membrane are employed as nanoprobes and bioassay platform, respectively. The whole assay can be carried out within 10 min, including incubation, labeling, and washing procedures, which allows both quantitatively time‐resolved (TR) and qualitatively visual detection of CEA.Advanced Science (2021). […]

Scientists study use of abundant enzyme in tumor cells to monitor cancer treatment

IMAGE: The team led by Carmen Ferreira-Halder at Unicamps Bioassay and Signal Tranduction Laboratory conclude that the molecule is associated with chemotherapy resistance and metastasis. view more  Credit: Roberta Ruela de Souza The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator […]

Molecular reporters expose the allies of the brain tumor — ScienceDaily

Glioblastoma is the most common malignant brain tumor in adults. Roughly five in every 100,000 people develop this type of cancer each year. The diagnosis amounts to a death sentence: Even after surgical resection followed by radiation and chemotherapy, the glioblastoma will kill the patient in a few months. This is because the tumor invariably […]

Molecular reporters expose the allies of the brain tumor

IMAGE: Previously only suspected, now made it visible thanks to the molecular reporter: where human tumor cells and brain cells of a mouse meet, the tumor cells have a different identity… view more  Credit: Gargiulo Lab, MDC Glioblastoma is the most common malignant brain tumor in adults. Roughly five in every 100,000 people develop this type […]

New experimental AI platform matches tumor to best drug combo — ScienceDaily

Only 4 percent of all cancer therapeutic drugs under development earn final approval by the U.S. Food and Drug Administration (FDA). “That’s because right now we can’t match the right combination of drugs to the right patients in a smart way,” said Trey Ideker, PhD, professor at University of California San Diego School of Medicine […]

Calcium bursts kill drug-resistant tumor cells

Credit: American Chemical Society Multidrug resistance (MDR)—a process in which tumors become resistant to multiple medicines—is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in ACS’ Nano Letters have developed […]

Calcium bursts kill drug-resistant tumor cells — ScienceDaily

Multidrug resistance (MDR) — a process in which tumors become resistant to multiple medicines — is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in ACS’ Nano Letters have developed […]

Oncotarget: Th1 cytokines potentiate apoptosis of breast cancer cells and suppress tumor growth

IMAGE: MK-2206 in conjunction with immunotherapy slows progression of rodent HER-2pos tumors. view more  Credit: Correspondence to – Gary K. Koski – dendritic_cell@hotmail.com Volume 11, Issue 30 of Oncotarget reported that previously, the authors showed that anti-estrogen drugs combined with a dendritic cell-based anti-HER-2 vaccine known to induce strong Th1-polarized immunity dramatically improved clinical response rates […]